underdominance

Engineered Translocation-based Underdominance Gene Drive

A recent paper by Buchman et al. in ACS Synthetic Biology details the development of an underdominance effect through engineered chromosomal translocations in Drosophila melanogaster. The principle of using underdominance as a mechanism for driving desirable genes into populations has […]

Synthetic Interspecies-like Incompatibility

Engineered synthetic species-like barriers were recently described by Maselko et al (2017) in Nature Communications and the work has interesting implications for genetic control strategies and gene drive containment. There is an ever-increasing interest in manipulating natural populations using genetic […]

Conditions for Successful Underdominance Gene Drive

Edgington and Alphey (2017) report their modeling efforts in the Journal of Theoretical Biology on conditions under which engineered underdominance gene drive systems could result in successful population replacement. Underdominance refers to a situation where heterozygotes are selected against within […]

Transgenic Underdominance: Pushing Transgenes into Populations.

Insect population replacement and suppression using transgenic strategies are being considered for insects of medical and agricultural importance. Rapidly increasing the frequency of transgenes in target populations after transgene release using genetic drive systems remains a significant challenge. Driving transgenes […]