In a recent Nature Communications publication Weinberg et al., (2019) report developing and testing a repertoire of inducible site-specific recombinases capable of being activated by different inducers such as small molecules, light, and temperature. While developed and tested in mammalian cells and transgenic mice, they will be widely useful in insect systems.
When transgenic mosquito technology was being developed an idea was floated to use genetically modified mosquitoes as flying syringes to deliver important antigens to immunize people against various pathogens. Informed consent among other things made this an overly complex problem […]
Huang et al (2016) have published a short review on insect genetic technologies in the Journal of Genetics and Genomics that could serve as a useful guide for those considering the development of genetic technologies for ‘their’ insect system. The […]
A rapid method for generating and finding ΦC31 landing sites (attP) with the desired expression characteristics as well as a new method for creating transgene arrays in vivo was recently described by Knapp et al (2015). Albeit these methods were […]
For mosquitoes the number of genetic modification technologies that can and have been applied continues to grow, and while still not as deep as the Drosophila toolbox the mosquito toolbox is still impressive in the right hands. Bernardini et al. […]
As Perrimon and colleagues point out chimeras or mosaics have played and continue to play an important role in our analysis of development. In Drosophilia the technology for creating mosaics is mature and powerful. Even before transgenic technologies provided precision […]
Marking cells has been a powerful tool for developmental biologists studying Drosophila melanogaster for many decades. Insect genetic technologies, in particular site specific recombination systems, have allowed this lineage marking and tracking method to become highly robust and controlable. Enhancer […]