CSIRO in Canberra, Australia
CSIRO in Canberra, Australia, is seeking an experienced Research Scientist to contribute to ground-breaking research projects within the Synthetic Biology Future Science Platform (SynBioFSP). The position will be focused on developing genome engineering technologies in invertebrates, including insects and corals, including the engineering of organelles and associated symbionts. The capacity to engineer organelles and symbionts could deliver enormous impacts to industrial and environmental applications of synthetic biology. Efficient organelle engineering tools have proven to be a major challenge for the synthetic biology community, and their development is a core strategic objective within the SynBioFSP. All evidence suggests that genome editing tools like CRISPR-Cas9 would function in organelles if the component parts could be transported into the appropriate cellular compartments. This position will focus on understanding protein and RNA transport from the nucleus and cytoplasm into organelles and endosymbionts, initially focusing on Drosophila melanogaster as a model system. The appointee would then use this knowledge to develop effective tools to engineer the genomes of organelles and symbionts in this and other plant and animal systems targeted within the SynBioFSP.