Andrew Paige
National Institutes of Health
Washington, DC United States

Areas of Expertise:
Vector Genetics and Ecology

Research Organisms:
Mosquitoes (Aedes, Anopheles, Culex)


Research Focus:

Our lab has identified genes encoding salivary proteins specific to disease-transmitting female mosquitoes. I am interested in using precise genetic technologies such as CRISPR-cas9 to create mutant knockouts of these genes with the goals of determining gene function and exploring their potential as candidates for transmission blocking vaccines. We are interested in the creation of stable lines with mutations in these salivary proteins to perform biochemical assays on the adult females. This will allow us to determine the specific function in vector-host-pathogen interactions and their potential for biomedical targets in the development of novel transmission blocking strategies for vector-borne diseases. I am also interested in using homology-directed repair for genetic knock-in and take advantage of selectable markers to ease in the screening of mutant lines.