Genome editing with engineered nucleases is an emerging technology that enables manipulation of targeted genes in many organisms and cell lines.
Development, Growth & Differentiation has devoted an entire issue to genome editing. The paper describing the successful use of TALENs in Drosophila, while nice work, give readers a sense of how fast the field of genome editing has been moving. The authors report a “rapid” 7 month turn-around time using TALENs. CRISPRs are much easier and faster to use although not without their own set of limitations.
This issue provides some useful resources for thinking about and planning genome editing projects.
DEVELOPMENT GROWTH & DIFFERENTIATION, Volume: 56, Issue: 1