A recent paper by Buchman et al. in ACS Synthetic Biology details the development of an underdominance effect through engineered chromosomal translocations in Drosophila melanogaster. The principle of using underdominance as a mechanism for driving desirable genes into populations has […]
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A recent modelling study by Dhole et al. in Evolutionary Applications has thus sought to compare the invasiveness of three gene drives previously described as either spatially or temporally self-limiting. Recent discussions on gene drives have begun to shift away […]
Perera et al. (2018) recently used CRISPR/Cas gene editing in Helicoverpa zea, a lepidopteran pest of many crops. The authors showed positive correlations between different concentrations of ribonucleoprotein (RNP) complexes and Cas9 protein with mutation percentage of the vermillion […]
In a recent PNAS article, Champer et al. report variable rates of gene drive-based resistance allele formation. Gene drives have shown early promise as the next big thing in controlling insects both for the benefit of agricultural production and reducing […]
In a recent paper in Genome Research Nakajima et al. 2018 propose an efficient gene editing strategy by nucleotide substitution that overcomes three general problems associated with current methods. First, indels caused by the traditional Cas9-induced Double Strand Breaks (DSB), […]
Komor et al. reviewed two strategies for genome editing that do not rely on the Double Strand Breaks (DSB) in a recent issue ACS Chemical Biology. The authors specifically address oligonucleotide-directed mutagenesis and base pairing. Possibly the most harmful type […]
In a recent study using zebrafish published in G3: Genes, Genomes, Genetics, Hu et al. (2018) conducted a comprehensive analysis of gene editing efficiency between Cas9 proteins and Cas9 mRNA, each fused with a nuclear-localization signal (NLS) in a different […]
In a recent report in PNAS, Buchman et al. (2018) describe the construction and development of a MEDEA-based gene drive system in the crop pest, Drosophila suzukii. Buchman et al revisited the MEDEA-based gene drive approach developed in D. melanogaster […]
In their recent review in Trends in Biotechnology, Zhang et al 2017 provide an overview of how the RNAi pathway can be utilized to control pests, how different insect pests provide unique challenges to overcome and how those challenges can […]
Recently, Stroble et al. (2018) published in the journal, eLIFE, a novel technique to quickly and efficiently develop homozygous transgenic lines. Although this method was tested in the genetic model organism, Tribolium castaneum, it could be of particular interest for […]