Dong et al. (2018) in a recent paper in PLOS Pathogens describe the results of the genetic inactivation of a broad-spectrum agonist of the malaria parasite, FREP1 (fibrinogen-related protein 1, member of an immune and pattern recognition gene family called […]
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Marshall and Akbari review a range of different proposed gene drive systems and discuss ways in which CRISPR may be useful in engineering them in a recent issue of ACS Chemical Biology. In the years since translocations were first suggested […]
A recent issue of ACS Chemical Biology includes some 25 articles on various aspects of CRISPR/Cas systems – mechanisms and applications. While not all of the articles will be of direct interest to insect biologists, many are and anyone working […]
The Recent review by Germani et al., on “Mosaic Analysis in Drosophila”, which appeared in January edition of Flybook of Genetics (http://www.genetics.org/content/208/2/473) discusses mosaicism, one of the finest and sophisticated techniques, which is not only well-utilized and established in Drosophila model […]
A recent review by Darrington et al. (2017) sets the stage for a suite of novel RNAi-based approaches to help extend the applicability of SIT to many more pest species. The sterile insect technique (SIT) has been successfully used for […]
Li et al. recently reported how systemic RNAi occurred in the western corn rootworm (WCR), Diabrotica virgifera virgifera, one of the most important maize pests in North America and a model for understanding the mechanism of RNAi. Efficiency of RNA […]
Redkmer – a computational tool to identify X-linked targets for CRISPR-based sex distortion in insects
In the inaugural volume of The CRISPR Journal, Philippos Papathanos and Nikolai Windbichler describe a computational pipeline they call redkmer, which identifies repetitive CRIPSR target sites for X-shredding systems in insects. Back in 2007, Windbichler et al. found that the […]
In the January 2018 issue of Pathogens and Global Health Adelman et al. seek to establish standard operating procedures (SOPs) for gene drive research in arthropods and ask fundamental questions as to why these procedures are necessary. At a time […]
In their recent paper in G3: Genes|Genomes|Genetics, Li et al. describe a highly efficient protocol for the generation of stable knockout lines using CRISPR/Cas9. The ability of effectively targeting and disrupting gene function is essential for gene functional analysis studies […]
The Journal of Responsible Innovation has published a special issue entitled: Roadmap to Gene Drives: Research and Governance Needs in Social, Political, and Ecological Context. This is a collection of 13 papers and is the outcome of workshop held in […]