underdominance

Underdominance. Heterozygotes are less fit than either possible homozygotes. 01 vs 00 or 11

standard Conditions for Successful Underdominance Gene Drive

Edgington and Alphey (2017) report their modeling efforts in the Journal of Theoretical Biology on conditions under which engineered underdominance gene drive systems could result in successful population replacement. Underdominance refers to a situation where heterozygotes are selected against within […]

A selfish gene (blue) spreading through a mosquito population

standard Insect Gene Drives – Reviewed and Compared

Champer et al have published a review on the topic of engineered gene drives to manipulate wild populations in a recent Nature Reviews Genetics. Recent attention on Cas9-based gene drive systems has raised the awareness of these types of genetic […]

standard Transgenic Underdominance: Pushing Transgenes into Populations.

Insect population replacement and suppression using transgenic strategies are being considered for insects of medical and agricultural importance. Rapidly increasing the frequency of transgenes in target populations after transgene release using genetic drive systems remains a significant challenge. Driving transgenes […]