nanoparticles

standard Nanoparticle-bound, Aerosolized siRNA Knockdown in Aphids

Thairu et al. (2017) report in Insect Molecular Biology their use of aerosolized siRNAs bound to nanoparticles to silence genes in the pea aphid, Acyrthosiphon pisum, while circumventing  the problem of rapid dsRNA degradation in the hemolymph of this species. […]

standard Carbon Quantum Dots for dsRNA Delivery

Das et al. (2015) in Applied Materials & Interfaces compare chitosan, silica and carbon quantum dot nanoparticles as dsRNA delivery platforms for silencing genes in larval mosquitoes. Direct injection of dsRNA into the hemocoel of insects has  been somewhat effective […]

standard RNAi-based therapeutics: Delivery is key and relevant to insects

Specific gene knockdown after exogenous small interfering RNA (siRNA) injection into humans and mammals holds great promise for therapeutic applications. But enthusiasm  waned and some predict its demise because of the manifold problems in delivering the technology. A new review […]

Nano particles

standard Plasmid DNA Nanoparticles – Insect Applications?

Non-viral delivery of DNA has been and remains a busy road for discovery and innovation in the field of gene therapy. Some ten years ago DNA nanoparticles were developed as a possible alternative to viral vectors among other reasons.   […]