midgut

Basic structure of a morpholino oligonucleotide

Morpholino use in Mosquitoes is Promising

Antisense technologies have had limited application because oligodexoynucleotides in vivo have very limited stability. This stability problem due to rapid degradation of short DNA molecules limits the bioavailability of the molecules. Over the years there has been an evolution of […]

Feeding or Microinjecting dsRNA into Aphids for Gene Silencing.

Aphid Hemolymph and Gut Degrade dsRNA

Aphids are sap-sucking insects of great economic importance, and recently the pea aphid Acyrthosiphon pisum had its genome sequenced and annotated.  Insect genetic technologies are in high demand for this insect but it is proving to be a real challenge. […]