high-fidelity

standard Another High-Fidelity SpCas9 Nuclease

Kleinstiver et al. describe in Nature their successful efforts to create high-fidelity SpCas9 nuclease variants that have high on-target efficiencies and low or no off-target effects.  The results are SpCas9-HF1. When using Cas9 or other engineered nuclease systems one hopes […]