HEG

Synthetic gene drive system based on site specific DNA endonucleases (homing endonucleases, ZFN, TALENS, Cas9). Target sites and homology arms are chosen so that the endonuclease and associated genes (gRNA and other transgenes) are copied into homologous chromosomes.

An Overview of Gene Drive

Gantz and Bier reflect on and consider the implications of Cas9-based genome editing on genetics in a recent Bioessays that is worth reading if you are trying to keep up on this rapidly evolving part of the genetics ecosystem. Not […]

Basics of Cas9 Activity

Cas9 Gene Drive & Classical Biological Control

Webber et al have published an Opinion essay in PNAS concerning the growing interest in using engineered endonucleases (Cas9 in particular) to create gene drive systems to combat invasive species. Homing endonucleases are well known and well studied site-specific endonucleases […]

Transgenic Underdominance: Pushing Transgenes into Populations.

Insect population replacement and suppression using transgenic strategies are being considered for insects of medical and agricultural importance. Rapidly increasing the frequency of transgenes in target populations after transgene release using genetic drive systems remains a significant challenge. Driving transgenes […]