standard CRISPR-SD, a programmable Cas9 approach to generating X-shredder lines in insects with XY mating systems

In a recent paper in Scientific Reports, Galizi, Hammond, et al report on the use of CRISPR-Cas9 to develop a sex-distortion system in Anopheles gambiae, which they termed CRISPRSD. Earlier, the group had demonstrated that transgenic An. gambaie expressing the […]

Anopheles gambiae

standard Gene Drive In Anopheles gambiae

Hammond et al.’s just published paper in  Nature Biotechnology is the second paper in a month demonstrating effective CRISPR-based gene drive in a mosquito vector of malaria.  In this case the main malaria vector in Africa, Anopheles gambiae. Gene drive […]

standard Anopheles gambiae Transgenesis Tool Box – Major Additions

Volohonsky et. al. (2015) in a just-published paper in G3 entitled  “Tools for Anopheles gambiae transgenesis”  describe a wealth of new tools for creating transgenic An. gambiae. There has been a protocol for Anopheles gambiae transgenesis for over 15 years, […]

Anopheles gambiae

standard Controlling Malaria Mosquitoes With Genetics

A chemical-free eradication method for the human malaria mosquito, Anopheles gambiae, that is self-sustaining and requires no additional inputs beyond ‘pushing the button’ to get it started, sounds fantastic. For geneticists it has not been terribly difficult to think of […]