CRISPRs

XOR Circuit: You get output only when there is input from A or B but not both or neither.

standard CRISPy Circuits

Sophisticated tools for genome modification allow investigators to devise ever-increasing complex genetic circuits. The Gal4 /UAS system is one example of a simple binary system. While powerful, this system does not allow for particularly complex genetic circuits to be assembled. […]

TALENs and CRISPRs

standard Multigene Mutagenesis of Silk Moth with CRISPRs.

Genome editing using CRISPR/Cas9 is changing the way we think about genome modification. The CRISPR system, because it relies on a small user-provide guide RNA (gRNA) to give the Cas9 endonuclease its sequence specificity, is easy to use, relative to, […]

standard Development, Growth & Differentiation Devote Issue to Genome Editing

Genome editing with engineered nucleases is an emerging technology that enables manipulation of targeted genes in many organisms and cell lines. Development, Growth & Differentiation has devoted an entire issue to genome editing.  The paper describing the successful use of […]