Kansas State University
Manhattan, KS United States
Areas of Expertise:
Structural Biology, Biochemistry
My current research concerns the role of serpins in the immune response of the malaria vector Anopheles gambiae. The immune system of mosquitoes is regulated by serine protease cascades that culminate in a molecular response to invading pathogens. Serpins are irreversible inhibitors of serine proteases and have been found to negatively regulate these pathways. We are currently investigating the structure/function relationship of mosquito serpins and their target proteases with the purpose of developing both late life acting insecticides and methods to limit the transmission of parasites through the mosquito vector.