The Merlin lab at Texas A&M University (https://www.merlinlab.org) has a position open immediately for a post-doctoral fellow to develop CRISPR/Cas9-mediated knock-in approaches in monarch butterflies to tag clock neurons in vivo and study the clock circuitry that controls seasonal behavior. Our mechanistic understanding of how circadian clocks drive the seasonal output at the molecular and cellular levels has been limited by the lack of robust seasonal behaviors in genetically tractable model systems, and the lack of powerful genomic and genetic tools in non-model species that display robust seasonal behaviors. The migratory monarch butterfly has emerged as a promising model to study the molecular and neuronal mechanisms by which circadian clocks control seasonal behaviors because it exhibits a compelling repertoire of clock-controlled seasonal traits, its clockwork is well characterized, and its genome is sequenced and amenable to CRISPR/Cas9-mediated genetic manipulation.
These studies will employ advanced molecular, genetic and cell imaging tools. Successful applicants should have a PhD in a related field, a demonstrated track record of productivity, and experience in molecular neurogenetics. Experience in tissue imaging is a plus, but is not a requirement. Qualified candidates will be expected to work both independently and as part of an interactive team. We offer a supportive working environment in a lively international research team.
Applicants should send (1) their CV, (2) a cover letter with a statement of research interests and career goals, and (3) the name, email and phone numbers of three references to Christine Merlin via email: firstname.lastname@example.org