Frank Criscione

standard Cas9-Mediated Gene-Drive In Mosquitoes

Gantz and Bier who demonstrated the fundamental principles of a Cas9-based gene drive system using Drosophila melanogaster in a publication earlier this year have recreated that system in the mosquito Anopheles stephensi with the help of collaborators.  Gantz et al. […]

standard Exchangeable Cassettes Controlled by Endogenous Genes

Two recent publications, Gnerer et al. and Diao et al., address the issue of recreating the fine transcriptional patterns of endogenous genes with binary expression systems in insects. Binary expression systems are extremely powerful tools for controlled gene manipulation. The […]

standard Transgenic Underdominance: Pushing Transgenes into Populations.

Insect population replacement and suppression using transgenic strategies are being considered for insects of medical and agricultural importance. Rapidly increasing the frequency of transgenes in target populations after transgene release using genetic drive systems remains a significant challenge. Driving transgenes […]

Meiotic drive in Drosophila melanogaster

standard The Road Ahead for Using Gene Drive Systems

Emerging technologies have employed chemical, ecological and genetic strategies for effective and economical pest management. The various strategies around the transgenic augmentation of pests has shown great promise in being able to combat vector borne diseases and eradicate agricultural pests […]