Technology Topics

Driving into doublesex

Kyrou et al. (2018) in a recent paper in Nature Biotechnology report identifying a highly conserved target site in the Anopheles gambiae fertility gene doublesex (dsx), that cannot tolerate mutations. They built a gene drive targeting this site in dsx […]

Female Lethality System in Lepidoptera

Zhang et al (2018) in a recent paper in PNAS report their successful integration of transgenes into the W chromosome of Bombyx mori.  Initially, they set out to place visible markers on the W. This would enable rapid and accurate […]

Improved HDR-Mediated Genome Editing

Jose Arturo Gutierrez-Triana and colleagues from Heidelberg University report in eLIFE a CRISPR/Cas9 based methodology that simultaneously decreases donor DNA multimerization and increases HDR single-copy integration. A common obstacle that CRISPR/Cas HDR mediated genome editing faces is the accurate and […]

Network Announcements


INVITATION FOR 1ST INTERNATIONAL MOLECULAR PLANT PROTECTION CONGRESS-ADANA, TURKEY, APRIL 10-13, 2019 Dear Colleagues, Molecular approaches are currently among the most popular topics in biological sciences and provide many opportunities in the solution of various problems. We have witnessed […]

IGTRCN 2018 Technical Workshop – July 22-27

2018 IGTRCN Technical Short Course on Insect Genetic Technologies: Theory and Practice July 22 – 27, 2018 The Insect Transformation Facility Institute for Bioscience and Biotechnology Research University of Maryland College Park Applications by April 2, 2018 (24 seats available) […]

Positions Available

PhD: sex conversion gene drives

A collaborative BBSRC funded PhD project is available with Prof Tracey Chapman (University of East Anglia) and Dr Philip Leftwich (Pirbright Institute) is available To use CRISPR/Cas9 gene editing to investigate the molecular pathways underpinning male/female sex determination, with the […]